选择与安慰剂相比的选择加强了开放式的安慰剂过敏症
Biya Tang1, Evan Livesey, Ben Colagiuri
1School of Psychology, The University of Sydney, Sydney, Australia.
Pain
|November 14, 2023
概括
提供患者在开放标签安慰剂 (OLP) 中的选择显著提高了疼痛缓解. 这种选择,而不是疼痛的变化,似乎促进了OLP低痛感,为疼痛管理提供了一种实际的策略.
科学领域:
- 疼痛研究 疼痛研究
- 精神病体医学是一种精神病体医学.
- 临床伦理学 临床伦理学
背景情况:
- 欺骗性的安慰剂可以缓解疼痛,但也引发了关于知情同意的伦理问题.
- 开放式安慰剂 (OLP) 提供了一种伦理替代品,但最大限度地减轻疼痛效应 (低疼痛症) 需要进一步调查.
研究的目的:
- 为了确定是否为患者提供OLPs管理的选择,增强了缺痛症.
- 为了研究预期和疼痛强度变化的作用在OLP低痛症.
主要方法:
- 132名健康志愿者被随机分为三个组:有选择的OLP,没有选择的OLP和自然史 (没有治疗).
- 在电皮刺激期间,OLP组经历了一致或可变的疼痛强度.
- 测量了预期水平,以评估它们的调解作用.
主要成果:
- 与没有选择的OLP相比,具有选择的OLP表现出显著更大的缺痛症.
- 预期调解了在提供选择时观察到的增强性低痛解症.
- 与自然史相比,没有选择的OLP没有发现显著的低痛感.
- 疼痛强度的变化没有影响OLP低痛症.
结论:
- 提供OLP管理的选择是增强疼痛缓解的有效策略.
- 基于选择的OLP管理,以期望为媒介,提供了一种具有成本效益的方法来改善疼痛管理结果.
- 这一发现对安慰剂在疼痛治疗中的临床应用有重大影响.
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