瘤微环境响应型一对一的分子工程纳米平台使NIR-II光成像导向组合癌症疗法成为可能
Gui-Long Wu1, Fen Liu1,2, Na Li1
1Department of Hepatopancreatobiliary Surgery, the First Affiliated Hospital, and Center for Molecular Imaging Probe of Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China.
Analytical chemistry
|November 14, 2023
概括
这项研究引入了一种新型可激活纳米平台 (FTEP-TBFc NP),用于精确的瘤成像和多模式癌症治疗. 它增强了光动力学和化学动力学治疗等疗法,从而改善了治疗结果.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 可激活纳米平台 (NP) 提供有针对性的瘤治疗,副作用最小.
- 基于近红外 (NIR) 的光疗剂对癌症治疗具有前景.
- 开发高效的成像指导治疗策略对于癌症治疗至关重要.
研究的目的:
- 设计和评估一种新的第二次近红外 (NIR-II) 光成像导向的有机光热纳米平台 (FTEP-TBFc NP).
- 为了研究化学动力学疗法 (CDT),光动力学疗法 (PDT) 和铁化诱导的协同效应,以加强癌症治疗.
- 探索谷氨 (GSH) 和硫化 (H2S) 在纳米平台治疗功效中的作用.
主要方法:
- 对GSH.敏感的分子工程光异常NP (FTEP-TBFc NP) 的合理设计.
- 用于瘤可视化的NIR-II光成像.
- 激光照射NIR (808nm) 激光照射,触发同时产生光,热和活性氧物种.
- 评估H2S介导的催化酶和细胞染色体c氧化酶 (COX IV) 的抑制.
- 评估GSH枯竭诱导的谷氨过氧化酶4 (GPX4) 的下调和铁灭症的诱导.
主要成果:
- FTEP-TBFc NP对GSH表现出敏感的反应,产生H2S,并在瘤微环境中传递铁素.
- 在808nm辐射下,NP同时产生光,热和单片氧,增强ROS生成以改善CDT和PDT.
- H2S抑制了catalase和COX IV,增强了CDT和低温光热疗法 (HPTT).
- 通过降低GPX4的调节,细胞内GSH度的降低扩大了CDT的有效性,并诱导了铁亡.
- 该纳米平台实现了特定的瘤成像指导的多式模式癌症治疗.
结论:
- FTEP-TBFc NPs代表了成像引导的多模式癌症治疗的多功能和高效平台.
- 响应GSH的H2S生成和ferroptosis诱导的战略为癌症治疗提供了一种新的方法.
- 这项工作为设计和应用可激活的生物医学光疗学提供了新的视角.
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