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Updated: Jul 11, 2025

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双抑制域iCAR提高了AND-NOT门CART策略的效率

Nathanael J Bangayan1, Liang Wang2, Giselle Burton Sojo2

  • 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095.

Proceedings of the National Academy of Sciences of the United States of America
|November 14, 2023
PubMed
概括

化学抗原受体 (CAR) T细胞疗法在固体瘤中面临挑战,原因是瘤外毒性. 这项研究使用双抑制域改善了抑制性CAR (iCAR),提高了固体瘤CAR T细胞疗法的安全性和选择性.

关键词:
AND-NOT逻辑网关是不是一个逻辑网关.仿制性抗原受体的仿制性抗原受体免疫疗法 免疫疗法抑制性CAR (iCAR) 的使用在点上,瘤外的毒性.

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