培养肉类细胞生物学方面的进步和挑战
Beatriz Martins1, Arthur Bister1, Richard G J Dohmen1,2
1Mosa Meat B.V., Maastricht, The Netherlands; email: beatriz@mosameat.com, arthur.bister@med.uni-duesseldorf.de, richard@mosameat.com, maria@mosameat.com, rui@mosameat.com, lea@mosameat.com, tobias@mosameat.com, joanna@mosameat.com, joana@mosameat.com, dhruv@mosameat.com, lieke@mosameat.com, sara@mosameat.com, joshuaeflack@gmail.com.
Annual review of animal biosciences
|November 14, 2023
概括
从动物细胞培养中培养肉类的生产提供了环境和动物福利的好处. 克服细胞生物学和非科学挑战是其可扩展,具有成本效益的成功和革命性食品生产的关键.
科学领域:
- 生物技术是生物技术.
- 细胞生物学 细胞生物学
- 食品科学 食品科学 食品科学
背景情况:
- 通过动物细胞培养生产的培养肉,为传统畜牧业提供了替代品.
- 这一新兴领域是由环境和动物福利方面的担忧驱动的.
- 显著的科学和商业兴趣已经出现,但这项技术还处于芽阶段.
研究的目的:
- 审查培养肉技术的关键进展.
- 确定突出的挑战,特别是在细胞生物学.
- 强调需要协调科学努力,以实现可扩展的生产.
主要方法:
- 专注于培养肉类生物工艺的细胞生物学方面.
- 讨论细胞类型选择,增殖,分化以及细胞与生物材料的相互作用.
- 分析整个生物过程中的挑战,从细胞培养到最终产品.
主要成果:
- 已经确定了培养肉类细胞生物学中的关键进展.
- 在优化细胞增殖,分化和生物材料相互作用方面仍然存在重大挑战.
- 非科学障碍包括监管批准,消费者接受和市场可行性.
结论:
- 解决细胞生物学瓶对于具有成本效益,可扩展的培养肉至关重要.
- 协调的科学努力对于应对剩余的技术挑战至关重要.
- 克服科学和非科学挑战可以彻底改变粮食生产.
相关概念视频
01:21Cell Culture
17.3K
Most vertebrate cells grow in vitro attached to a substrate as a monolayer, called adherent cultures. The flasks and plates used to grow cells are chemically treated to facilitate cell attachment. However, a few cell types, such as hematopoietic cells, can grow in a suspension. In contrast to adherent cultures, suspension cultures can grow in non-treated cultureware using magnetic stirrers or spinner flasks to agitate the culture media
17.3K
01:16Cell Lines
7.5K
A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...
7.5K