诊断延迟对乳病的严重程度的影响
Shubham Mehta1, Ankit Agarwal1, Aditya Vikram Pachisia1
1Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
Journal of gastroenterology and hepatology
|November 14, 2023
概括
延迟诊断腹腔疾病 (CeD) 显著恶化其严重程度. 较长的诊断延迟与状缩增加和较高的抗体标位相关,突出显示了临床实践中早期检测的必要性.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 病 (CeD) 影响全球0.67%,但诊断往往会延迟.
- 未被诊断的CeD会导致疾病严重程度和并发症的增加.
研究的目的:
- 调查诊断延迟对乳病严重程度的影响.
- 为了确定与延迟CeD诊断相关的因素.
主要方法:
- 726名CeD患者的临床记录的回顾性审查.
- 对人口统计,症状,诊断的时间,IgA抗tTG抗体水平和小异常严重性的分析 (修改的马什分类).
主要成果:
- 诊断延迟的中位数为27个月 (IQR12-60个月).
- 较长的延迟与年龄相对较低的身高,较低的血红蛋白,高的IgA抗tTG,以及增加的状/隐形异常相关.
- 18%的非胃肠道症状患者经历了更长的诊断延迟.
结论:
- 在CeD诊断中显著的延迟是常见的.
- 诊断延迟加剧了CeD的严重程度.
- 在相关的临床场景中,建议在CeD诊断方面使用较低的值.
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