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Updated: Jul 11, 2025

Optimizing the Genetic Incorporation of Chemical Probes into GPCRs for Photo-crosslinking Mapping and Bioorthogonal Chemistry in Live Mammalian Cells
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具有TAAR1优选激素设计的结构和信号机制

Pan Shang1, Naikang Rong1, Jing-Jing Jiang2

  • 1NHC Key Laboratory of Otorhinolaryngology, Qilu hospital and School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, China; Advanced Medical Research Institute and Meili Lake Translational Research Park, Shandong University, Jinan, Shandong 250012, China.

Cell
|November 14, 2023
PubMed
概括

由内源代谢物和药物激活的微氨基相关受体1 (TAAR1) 揭示了精神分裂症治疗的结构性见解. 针对特定的口袋调节信号, 提供超越传统G路径的新治疗途径.

关键词:
一个GPCR时间表化电磁结构精神分裂症微氨基关联受体

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