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一个对压力敏感的前静脉电路支持努力寻求奖励的行为
Robert N Fetcho1, Puja K Parekh2, Jolin Chou2
1Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10021, USA; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, Weill Cornell Medicine, New York, NY 10021, USA; Department of Psychiatry, Weill Cornell Medicine, New York, NY 10021, USA.
Neuron
|November 14, 2023
概括
精力评估对于决策至关重要,它涉及前带带皮层 (ACC) 投射到核 (NAc). 压力会破坏这个ACC-NAc电路,影响动机和努力寻求奖励的行为.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 行为经济学是一种行为经济学.
背景情况:
- 努力评估是决策的关键,根据奖励价值和所需的努力指导行动选择.
- 前带带皮层 (ACC) 参与了劳动力评估,但其精确的电路级机制仍然不清楚.
- 慢性压力会扰乱努力的估值,强调需要了解所涉及的神经回路.
研究的目的:
- 研究前带状皮层 (ACC) 神经元向核 (NAc) 投射的神经元在调节基于努力的决策中的作用.
- 阐明ACC-NAc电路活动如何整合奖励和努力信息.
- 检查慢性压力对ACC-NAc电路功能和相关行为的影响.
主要方法:
- 利用小鼠模型研究努力估值行为.
- 在决策任务期间在ACC-NAc预测中记录的神经活动.
- 用慢性皮质来诱导压力,并评估其对行为和神经信号的影响.
主要成果:
- 发现ACC-NAc神经元对于小鼠的努力评估行为至关重要.
- 在ACC-NAc细胞中的活动整合了奖励和努力信息,编码了一个与努力要求相适应的信号.
- 长期暴露于皮质降低了动机,损害了努力的奖励寻求,并破坏了ACC-NAc神经信号.
结论:
- 对压力敏感的ACC-NAc电路在支持努力寻求奖励的行为中发挥着关键作用.
- 这个电路集成了奖励和努力信号,以加强努力分配,以最大限度地获得奖励.
- 了解这种循环可以了解压力诱导的动机缺陷和潜在的治疗目标.
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