暴露于金属混合物和不良的怀孕和分娩结果:一个系统的审查
Ibrahim Issah1, Mabel S Duah2, John Arko-Mensah3
1West Africa Center for Global Environmental & Occupational Health, College of Health Sciences, University of Ghana, Legon, Accra, Ghana; Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana.
The Science of the total environment
|November 14, 2023
概括
产前暴露于金属混合物与不良出生结果有关. 本次审查强调了混合分析的必要性,以了解现实世界的风险,并为保护策略提供信息.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 产前暴露于金属混合物是一个越来越令人担忧的问题,与不良的怀孕和分娩结果有关.
- 以前的研究往往分析单个金属,未能捕捉复杂的真实世界的暴露场景.
研究的目的:
- 系统地审查和评估金属混合物与怀孕/分娩结果之间的关联.
- 确定研究缺口,并为未来的研究和公共卫生政策提供信息.
主要方法:
- 遵守PRISMA和COSMOS-E系统审查指南.
- 在PubMed,MEDLINE和SCOPUS数据库中进行全面的文献搜索.
- 使用NOS和AXIS工具进行方法质量评估.
主要成果:
- 包括34项研究,调查出生体重,新生儿大小,早产等.
- 在各种金属混合物 (例如,Hg,As,Pb,Cd) 和不良结果之间发现了显著的关联.
- 在混合物中的金属之间展示了多种效应和潜在的相互作用.
结论:
- 怀孕期间接触金属混合物与不良分娩结果始终有关.
- 混合分析方法虽然需要谨慎,但与传统方法相比,可以提供更好的洞察力.
- 进一步的研究对于阐明金属混合物风险的机制和制定减轻风险的策略至关重要.
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
The Periodic Table and Organismal Elements
179.6K
Overview
179.6K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
300
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
300


