高压氧气疗法与重复性跨脑磁性刺激对血管认知障碍的影响:一个随机对照试验协议
Wei Xie1,2, Xinxin Chen1,2, Xichao Ma1,2
1Department of Rehabilitation Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
BMJ open
|November 14, 2023
概括
这项研究研究了高压氧气疗法 (HBOT) 和重复性跨磁刺激 (rTMS) 对血管认知障碍 (VCI) 的联合作用. 该试验的目的是确定这种组合是否比单个治疗或传统护理提供更好的认知康复.
科学领域:
- 神经科学是一个神经科学.
- 临床医学 临床医学
- 康复科学 康复科学 康复科学
背景情况:
- 血管认知障碍 (VCI) 是一个日益严重的全球健康问题,严重影响日常生活和生活质量.
- 目前对VCI的康复计划有限,这凸显了对新型治疗策略的需求.
- 高压氧气疗法 (HBOT) 和重复性横磁性刺激 (rTMS) 单独显示出对认知增强的承诺.
研究的目的:
- 评估联合HBOT和rTMS在改善VCI患者的认知功能方面的疗效.
- 为了比较联合HBOT和rTMS与单独的HBOT,单独的rTMS和常规治疗的效果.
主要方法:
- 一个单中心,评估者盲目的随机对照试验,在四个并行臂中,有72名参与者.
- 参与者将被分配到对照组,HBOT,rTMS或组合HBOT和rTMS组,持续4周的干预期.
- 认知功能,日常生活活动和神经生理学标志物将在基线,干预后和随访期间进行评估.
主要成果:
- 主要结果:蒙特利尔认知评估 (MoCA) 得分.
- 二次结果包括迷你精神状态检查 (MMSE),修改的巴特尔指数 (MBI),P300事件相关的潜力,以及功能近红外光谱 (fNIRS) 测量大脑血液动力学.
- 将分析数据以确定治疗组之间的显著差异.
结论:
- 这项试验将为联合HBOT和rTMS作为VCI的先进康复策略的潜力提供关键的见解.
- 预计这些发现将为临床实践提供信息,并指导未来对VCI治疗的研究.
- 在同行评审期刊上发表和在科学会议上传播将确保结果的广泛获取.
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