[癌症患者风险因素控制与生存之间的关联]
1Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, China.
Zhonghua yi xue za zhi
|November 14, 2023
概括
实现更多的心血管风险因素目标可以显著降低癌症患者的死亡率. 这包括所有原因,动脉样硬化心血管疾病 (ASCVD) 相关的和癌症特异性死亡率,特别是在患有呼吸道或生殖癌症的老年男性中.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 心血管风险因素在癌症患者中很普遍.
- 管理这些因素可能会影响患者的生存率.
- 关于多重风险因素控制与癌症幸存者死亡率之间的关联的数据有限.
研究的目的:
- 研究心血管风险因子目标的实现与癌症患者的死亡率结果之间的关联.
- 分析对全因死亡率,动脉样硬化心血管疾病 (ASCVD) 相关死亡率和癌症相关死亡率的影响.
主要方法:
- 分析了一组2079名新诊断的癌症患者,没有先前存在的ASCVD.
- 根据达到0-1,2,或≥3个心血管风险因子目标 (血压,葡萄糖,LDL-C,hs-CRP) 来分组患者.
- 使用多变量考克斯回归模型来评估死亡风险,并根据许多共同变量进行调整.
主要成果:
- 与达到≤1目标相比,实现≥3个风险因素目标与所有原因死亡率 (HR 0.68),ASCVD死亡率 (HR 0.35) 和癌症死亡率 (HR 0.60) 的风险显著降低有关.
- 观察到死亡率下降的显著趋势,目标风险因素的数量越来越多.
- 亚组分析显示,在60岁以上的男性患者和患有呼吸道或生殖癌症的患者中,相关性更强.
结论:
- 实现更多的心血管风险因素目标与癌症患者的生存率改善有显著的关联.
- 这种关联在老年男性患者和患有呼吸道或生殖系统癌症的患者中尤为明显.
- 优化心血管风险因素管理可能是提高癌症患者生存率的关键策略.
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