[消化道癌与冠状动脉疾病的严重程度之间的关联]
1Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China.
Zhonghua yi xue za zhi
|November 14, 2023
概括
消化道癌症患者患有严重冠状动脉疾病的风险更高. 这种关联在具有高中性粒细胞与淋巴细胞比率 (NLR) 水平的个体中特别强烈,这表明炎症.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 炎症研究 炎症研究
背景情况:
- 冠状动脉疾病 (CAD) 严重程度评估对于患者管理至关重要.
- 癌症患者的全身炎症标志物和CAD之间的关系是一个正在积极研究的领域.
- 消化道癌症对全球健康构成重大负担.
研究的目的:
- 调查消化道癌症与冠状动脉疾病的解剖学严重程度之间的关联.
- 探索炎症的作用,以中性粒细胞与淋巴细胞比率 (NLR) 表示,在这种关联中.
主要方法:
- 追溯病例对照研究比较了142名消化道癌症患者和426名匹配的非癌症患者.
- 冠状动脉疾病的严重程度使用SYNTAX得分 (SX) 来评估冠状动脉血管学.
- 根据高SYNTAX分数 (SXhigh,≥22) 和高NLR (NLRhigh,≥2.287) 分类的患者.
- 用于确定关联的物流回归分析.
主要成果:
- 与非癌症患者相比,消化道癌症患者的SXhigh比例明显高 (33.1%对23.9%,P=0.032).
- 消化道癌独立地与较高的CAD严重程度相关 (OR:1.614,P=0.029).
- 在NLRhigh小组中,消化道癌症患者的严重CAD风险显著增加 (OR:1.948,P=0.048),这一关联在NLRlow小组中没有观察到.
结论:
- 消化道癌与冠状动脉疾病的解剖学严重性增加有关.
- 患有消化道癌症的患者患有严重冠状动脉疾病的风险更高.
- 高系统性炎症 (高NLR) 放大了消化道癌和严重冠状动脉疾病之间的关联.
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