相关实验视频
Updated: Jul 11, 2025
04:23
Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
2.2K
[复合人血栓对肝切除血静的作用:一项随机对照III期临床试验]
1Department of Hepatobiliary and Pancreatic Surgery, the Second Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhonghua yi xue za zhi
|November 14, 2023
概括
再组合人体血栓在肝脏手术中有效地停止出血,与安慰剂相比显示出更高的血静. 该疗法在临床试验中显示出良好的安全性和低免疫性.
科学领域:
- 外科手术静血 静血是什么
- 生物制剂和再生医学 生物制剂和再生医学
背景情况:
- 切除肝脏的手术往往涉及到持续的出血,尽管传统的静血方法.
- 有效的血液静止对于患者的安全和减少肝脏手术期间并发症至关重要.
研究的目的:
- 评估复合人体血栓在肝脏伤口中的静脉效果.
- 评估复合人血栓在接受肝切除的患者中的安全性和免疫性.
主要方法:
- 一个多中心,随机,双盲,安慰剂控制的III期试验.
- 复合人体血栓与安慰剂的比较在348名患有浸肝脏伤口的患者中.
- 主要终点:血液静止率在6分钟内;安全性和免疫性 (抗药抗体) 在手术后进行评估.
主要成果:
- 与安慰剂 (44.0%) 相比,复合人类血栓在6分钟内实现了显著更高的血静率 (71.6%) (P<0.001).
- 没有报告3级以上与药物相关的不良事件或死亡.
- 没有观察到可检测的抗药抗体或与复合人血栓使用相关的中和抗体.
结论:
- 复合人体血栓是有效的止血剂,用于控制肝切除手术中的出血.
- 该药物具有良好的安全性,具有较低的免疫性.
- 复合人体血栓的局部应用为具有挑战性的手术出血场景提供了有希望的解决方案.
相关概念视频
01:29Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
719
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
719