[阻塞性睡眠呼吸暂停和高血压患者的血管损伤之间的关联]
1Department of Hypertension, TEDA International Cardiovascular Hospital, Tianjin University, Tianjin 300457, China.
Zhonghua xin xue guan bing za zhi
|November 14, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 与高血压患者的血管内皮损伤有关. 这种关联在患有中度至重度OSA的年轻患者中尤为明显.
科学领域:
- 心血管医学 心血管医学
- 睡眠医学 睡眠医学
- 高血压研究 高血压研究
背景情况:
- 高血压是心血管疾病的主要危险因素.
- 阻塞性睡眠呼吸暂停 (OSA) 越来越多地被认为是高血压患者的并发症.
- 在高血压中OSA严重程度对血管损伤的影响需要进一步阐明.
研究的目的:
- 为了研究阻塞性睡眠呼吸暂停 (OSA) 和其严重程度之间的关系,通过呼吸暂停-呼吸暂停指数 (AHI) 表示,以及高血压患者的血管损伤.
- 探索与特定的血管参数的相关性,如流媒体血管扩张 (FMD) 和动脉硬.
- 为了确定这种关联是否在年轻和年长的高血压患者之间有所不同.
主要方法:
- 一项涉及555名成年高血压患者进行便携式睡眠监测的横截面研究.
- 评估血管参数,包括口病,喉内膜厚度和脉冲波传导速度 (cfPWV,baPWV).
- 使用多变量逻辑回归和子组分析来确定OSA严重程度 (轻度,中度,重度) 和血管损伤标志物之间的关联.
主要成果:
- 在包括的高血压患者中,OSA的患病率为66.7%.
- 中度和重度的OSA与血管内皮损伤 (FMD<6.0%) 有显著的关联.
- 在年轻的高血压患者 (年龄≤45岁) 中,OSA严重程度 (包括AHI水平) 与血管内皮损伤的相关性更强.
结论:
- 阻塞性睡眠呼吸暂停与高血压患者的血管内皮损伤有显著的相关性.
- 由于OSA,血管内皮损伤的风险在年轻的高血压患者中特别高.
- 没有发现OSA严重程度与大脑动脉内脏介质厚度或动脉硬之间有显著的相关性.
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