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唐氏综合征中的角膜:患病率,危险因素,严重程度和角膜断层扫描特征

Joyce J Mathan¹, Akilesh Gokul¹, Samantha K Simkin¹

¹Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Clinical & experimental ophthalmology

|November 14, 2023

概括

在患有唐氏综合征 (DS) 的人群中,角是普遍存在的,影响26.3%的参与者. 对于那些患有DS的人来说,建议通过角膜断层扫描查进行早期检测.

科学领域:

眼科医生眼科眼科
遗传学是一个遗传学.
医疗成像医学成像

背景情况:

唐氏综合征 (DS) 与异常的角膜特征有关.
以前的研究表明,在DS患者中,角膜异常的患病率较高.
这项研究专门研究DS中的角,包括其风险因素和严重程度.

研究的目的:

为了确定患有唐氏综合征的个体中角质的患病率,危险因素和严重程度.
在唐氏综合征患者和没有角膜的角膜断层扫描特征的特征.
评估角膜断层扫描在这个人群中用于角膜查的实用性.

主要方法:

一项前性观察性研究包括190名10岁及以上的唐氏综合征患者.
参与者接受了全面的眼科检查,包括裂灯生物显微镜,Scheimpflug角膜断层扫描,角膜拓和自折.
的诊断 (DS-KC,DS-SK,DS-NK) 是通过对扫描进行专家审查来确定的.

主要成果:

在50名 (26.3%) 参与者中诊断出了角.
眼部摩擦被确定为角质的一个显著风险因素 (p=0.036).
角膜断层扫描发现,角膜,疑似角膜和非角膜群体之间的最大角膜测量和后部升高有显著差异 (p<0.001).

结论:

角是唐氏综合征患者常见的疾病.
角膜断层扫描是早期检测DS患者角膜的一个有价值的工具.
对于患有唐氏综合征的人来说,建议定期对角膜断层扫描进行查.

关键词:

角膜角膜角膜是一个角膜断层扫描角膜断层扫描唐氏综合征是什么意思形 (keratoconus) 是一种形.

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