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Updated: Jul 11, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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超膜β-桶模型的α-Synuclein寡合体

Manuela Maurer1, Themis Lazaridis1

  • 1Department of Chemistry & Biochemistry, City College of New York/CUNY, 160 Convent Ave, New York, New York 10031, United States.

Journal of chemical information and modeling
|November 14, 2023
PubMed
概括

阿尔法-同核素寡合体可能通过形成跨膜β-桶来损害细胞. 模拟显示这些结构可以插入膜,其稳定性取决于特定的蛋白质区域和质突状态,为神经退行性疾病机制提供了洞察力.

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