胎盘术语中的霍夫尔细胞功能与成人心血管和抑郁症结局有关
Eamon Fitzgerald1,2,3, Mojun Shen4, Hannah Ee Juen Yong4
1Sackler Program for Epigenetics and Psychobiology, McGill University, Montréal, Canada. eamon.fitzgerald@mcgill.ca.
Nature communications
|November 14, 2023
概括
胎盘炎症影响成人健康. 这项研究确定了一种胎盘炎症的特征,当被感染或早产扰乱时,会增加心血管疾病和抑郁症的风险,阿司匹林有可能调节这种风险.
科学领域:
- 生殖生物学和围产医学
- 免疫学和炎症 免疫学和炎症
- 遗传学和基因组学 在
- 心血管和精神病学流行病学
背景情况:
- 胎盘炎症与成人疾病风险有关,但其在健康怀孕中的作用尚不清楚.
- 炎症介质存在于胎盘中,特别是在霍夫尔细胞中,在病理和恒温的条件下.
- 了解胎盘对长期健康结果的贡献,对于预防策略至关重要.
研究的目的:
- 在术语"胎盘"中定义与炎症相关的基因表达特征.
- 调查这种胎盘特征与成人心血管和抑郁症结局的关联.
- 探索这种胎盘炎症特征的潜在调节剂.
主要方法:
- 在胎盘霍夫尔细胞中定义了一种与炎症相关的表达特征.
- 利用表达量的特征位点 (eQTLs) 来开发一个多基因分数 (PGS) 来预测签名表达.
- 在英国生物库使用PGS进行了全现象关联和门德尔随机化研究.
- 分析了对胚胎内感染和早产标记物的基因丰富.
主要成果:
- 确定了胎盘炎症模块对心血管和抑郁症结局的保护性,取决于性别的影响.
- 发现,因胚胎内感染和早产而失调的基因在这个模块内有显著的代表性.
- 确定阿司匹林是胎盘炎症特征的潜在调节剂.
结论:
- 通过早产或产前感染破坏胎盘霍夫尔细胞功能,有助于增加抑郁症和心血管疾病的风险.
- 鉴定的胎盘炎症特征对成年人的健康有明显的影响,具有性别特异性的影响.
- 研究结果表明,阿司匹林等潜在的治疗点可以缓解与胎盘炎症相关的不良成年健康结果.
相关概念视频
01:24Gonadal and Placental Hormones
1.5K
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
1.5K
01:14Fetal Circulation
1.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
1.0K
01:07Development of Blood Vessels
601
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
601
01:27Psychoneuroimmunology: Cardiovascular Disease
33
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
33
01:07Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K