上层结核双向调节前额叶皮层的选择活动
Alyse Thomas1, Weiguo Yang1, Catherine Wang1
1Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Nature communications
|November 14, 2023
概括
在决策过程中,上层结核 (SC) 调节前额皮层活动. 这项研究揭示了SC如何影响大脑中的选择竞争和行动选择.
科学领域:
- 神经科学是一个神经科学.
- 决策方式 决策方式
- 行动选择行动选择
背景情况:
- 行动选择涉及选择之间的竞争.
- 额叶皮层和上结核 (SC) 中的神经活动与选择竞争相关.
- 这些地区在调解选择竞争中的互动并未得到充分理解.
研究的目的:
- 为了研究前皮层和上层结核 (SC) 在调解选择竞争中的相互作用.
- 为了确定SC是否可以在决策过程中调节前皮层活动.
主要方法:
- 使用鼠标模型进行定向任务.
- 在前皮层和SC的地形匹配区域记录了神经活动.
- 在SC中操纵特定的神经元群体 (GABAergic和glutamatergic).
主要成果:
- 确定了一个下降的运动路径和前额叶皮和SC之间的回入循环.
- 在两个区域观察到不同的神经元群体,它们编码了对立的选择,并表现出竞争.
- 证明激活或抑制SC GABAergic和glutamatergic神经元双向地改变了前皮层活动.
结论:
- 上层结体 (SC) 在双向调节选择竞争方面发挥着至关重要的作用.
- 脑前皮层通过在前皮层驱动活动来影响行动选择.
- 确定了SC作为在行动选择网络中规范选择竞争的关键节点.
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