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Updated: Jun 1, 2026

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
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多原子分析揭示了不一致的免疫原特性和黑色素瘤脑转移中独特的瘤微环境

Gino K In1, Jennifer R Ribeiro2, Jun Yin2

  • 1Division of Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Gino.In@med.usc.edu.

NPJ precision oncology
|November 14, 2023
PubMed
概括

与其他黑色素瘤类型不同,黑色素瘤脑转移显示抑制免疫活性和增加氧化酸化. 准代谢和血管生成途径可能会提高免疫治疗对这些具有挑战性的瘤的有效性.

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...