炎症是进展性神经疾病的常见联系
Ana Dias-Carvalho1,2, Susana Isabel Sá3,4, Félix Carvalho5,6
1Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Portugal. arcdc97@gmail.com.
Archives of toxicology
|November 14, 2023
概括
随着人们寿命的延长",炎症" (随着年龄的增长而增加的炎症) 导致与年龄相关的神经系统疾病. 了解炎症的理解 炎症的理解
科学领域:
- 老年学和神经科学研究
- 免疫学和衰老研究研究
背景情况:
- 由于与年龄相关的疾病倾向,预期寿命的增加给医疗保健系统带来了挑战.
- 衰老与高度的促炎状态有关,称为"炎症",这是生物衰老的关键因素.
- 炎症与许多与年龄有关的疾病有关,并假设在神经系统疾病中发挥作用.
研究的目的:
- 探索炎症和与年龄有关的神经系统疾病的发病之间的联系.
- 了解外周炎症如何影响大脑功能并导致神经退行.
- 突出炎症在发展对进展性神经疾病的干预措施的重要性.
主要方法:
- 对有关衰老机制,炎症和神经系统疾病的现有文献进行审查.
- 分析衰老和神经系统疾病发展之间的共同路径.
- 检查周围炎症对中枢神经系统功能的影响.
主要成果:
- 衰老和神经系统疾病有着共同的基本路径,汇聚在炎症上.
- 周围炎症显著影响大脑功能,是导致阿尔茨海默病,帕金森病和多发性硬化症的因素.
- 炎症是与年龄相关的神经疾病发展的关键组成部分.
结论:
- 炎症是生物衰老的重要决定因素,也是与年龄有关的疾病的基石.
- 了解炎症在神经系统疾病的发病过程中的作用,对于治疗的发展至关重要.
- 针对炎症提供了一种有希望的策略,可以减缓疾病的进展,并减少神经疾病的社会负担.
更多相关视频
09:35Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
Published on: May 19, 2020
9.4K
09:46Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
Published on: September 21, 2021
4.8K
相关概念视频
Disorders of the Nervous Tissue
1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Inflammation
53.7K
Overview
53.7K
Parkinson's Disease: Overview
564
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
564
Neural Regulation
39.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.5K
The Blood-brain Barrier
47.4K
Overview
47.4K
Myocarditis I: Introduction
9
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
9
