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患有自身免疫性类风湿性疾病的青少年女孩的卵巢功能障碍
Mohamed Taman1, El-Hadidy Nm2, Hamed Yousef3
1Assistant professor of Obstetrics & Gynecology, Faculty of Medicine, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt.
Pediatric rheumatology online journal
|November 14, 2023
概括
在患有自身免疫性类风湿性疾病 (ARD) 的青少年女性中,月经异常很常见. 在青少年系统性红斑狼 (JSLE) 中,系统性狼国际合作诊所/美国风湿病学院 (SLICC/ACR) 损伤指数,而不是类固醇剂量,预测了这些问题.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 自身免疫性类风湿性疾病 (ARDs) 可以影响青少年女性的内分泌和生殖健康.
- 年轻患者的月经和青春期发育可能会受到干扰,这些患者患有诸如青少年异常性关节炎 (JIA),青少年系统性红斑狼 (JSLE) 和青少年皮肤肌炎 (JDM) 等疾病.
研究的目的:
- 研究被诊断为ARD的青少年女性月经和青春期异常的患病率和预测因素.
- 在不同的ARD中区分疾病活动和治疗对生殖健康的影响.
主要方法:
- 对患有JIA,JSLE和JDM的青少年女孩 (13-18岁) 的回顾性分析.
- 妇科评估包括超声波,以及人口统计,临床,疾病和荷尔蒙数据的审查.
- 后勤回归分析以确定月经异常的独立预测因素.
主要成果:
- 在47.6%的JSLE患者,17.4%的JIA患者和1名JDM患者中观察到月经异常.
- 高系统性狼国际合作诊所/美国风湿病学学院 (SLICC/ACR) 损伤指数,累积类固醇剂量和更早的青春期开始与JSLE的月经不规则有关.
- 在JSLE中,SLICC/ACR损伤指数是最重要的月经异常预测指标.
结论:
- 在ARD的青少年女性中,月经障碍很常见.
- SLICC/ACR损伤指数是JSLE月经异常的关键决定因素,超过累积类固醇使用或疾病持续时间.
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