长期COVID中的咳和唾液与严重的急性COVID-19有关:一项日本队列研究
Mayuko Watase1,2, Jun Miyata3, Hideki Terai4,5
1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Respiratory research
|November 15, 2023
概括
长期COVID患者经历持续咳和吐往往与严重急性COVID-19有关. 识别风险因素,如通风支持,对于管理这些长期呼吸道症状至关重要.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 长期COVID的特点是急性COVID-19后的长期症状,经常包括持续的咳和唾液.
- 识别这些呼吸道症状的危险因素对于患者管理至关重要.
研究的目的:
- 确定长期COVID患者长期咳和唾液相关的特定风险因素.
- 为了调查急性COVID-19严重程度和持续的呼吸道症状之间的相关性.
主要方法:
- 一项涉及住院COVID-19患者 (18岁以上) 的多中心队列研究.
- 通过医疗记录,问卷和智能手机应用程序在3,6和12个月的随访期间收集的数据.
- 统计分析包括单变量和多变量逻辑回归,以及卡普兰-梅尔曲线.
主要成果:
- 持续咳和唾液与严重的急性COVID-19指标 (成像,器官功能障碍,血栓栓塞,特定生物标志物) 有关.
- 间歇性强制通风 (IMV) 和年龄较大被确定为危险因素.
- 急性COVID-19感染的严重程度与长时间的咳和唾液产生有关.
结论:
- 在日本长期COVID患者中,持续的咳和唾液与严重的急性COVID-19有很强的联系.
- 预防策略,包括疫苗接种和治疗进展,建议高危人群采取预防策略,以减轻持续的呼吸道症状.
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