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非选择性β adrenoceptor阻断剂的使用和帕金森病的风险:来自多个现实世界的证据
Zeying Feng1,2, Qiuping Zhao3, Jingjing Wu2
1Clinical Trial Institution Office, Liuzhou Hospital of Guangzhou Women and Children's Medical Center, Liuzhou, China.
BMC medicine
|November 15, 2023
概括
定期使用非选择性β-上腺受体抑制剂 (NBBs) 与患帕金森病 (PD) 的风险更高有关. 考虑替代高血压治疗来减轻这种风险.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 高血压是帕金森病 (PD) 的已知危险因素.
- 流行病学研究显示,关于抗高血压药物对PD风险的影响,结果各不相同.
- 这项研究调查了特定的抗高血压药物类别及其与PD发生和进展的关联.
研究的目的:
- 为了确定特定的抗高血压药物类别是否提高或降低帕金森病的风险.
- 利用多源数据分析抗高血压药物使用与帕金森病风险之间的关联.
主要方法:
- 美国食品和药物管理局不良事件报告系统 (FAERS) 数据的不成比例性分析.
- 12项研究的元分析和英国生物银行队列分析.
- 门德尔随机化 (MR) 分析,以评估药物标和PD风险之间的因果关系.
主要成果:
- 根据FAERS分析,非选择性β-上腺受体抑制剂 (NBB) 与PD风险增加有关 (ROR = 3.13).
- 分析 (12,183,809名参与者) 显示,与NBB一起增加了PD风险 (RR = 1.64).
- 英国生物库队列 (105,763名参与者) 证实使用NBB增加了PD风险 (HR = 1.47).
- 核磁共振分析表明,PD风险降低,ADRB2基因表达高 (OR = 0.85),这是NBBs的目标.
结论:
- 定期使用非选择性β adrenoceptor阻断剂 (NBBs) 与帕金森病的风险增加有关.
- 研究结果表明,NBB可能对PD发展产生不利影响.
- 对于患PD风险较高的人来说,替代性抗高血压治疗可能是值得推的.
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