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大脑小脑体积和疾病在帕金森病中的分期:一个ENIGMA-PD研究

Rebecca Kerestes¹, Max A Laansma^2,3, Conor Owens-Walton⁴

¹Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Movement disorders : official journal of the Movement Disorder Society

|November 15, 2023

概括

帕金森病 (PD) 显示出明显的小脑变化. 早期的PD涉及较大的运动区域,而晚期的PD则涉及较小的非运动区域,影响认知.

科学领域:

神经成像是一种神经成像.
神经退行性疾病神经退行性疾病
大脑小叶的功能

背景情况:

越来越多的证据表明小脑与帕金森病 (PD) 的病理生理学有关.
在PD的区域大脑小脑变化,特别是关于运动和非运动功能的变化,需要进行详细的研究.

研究的目的:

在患有帕金森病 (PD) 的人群中,用3D T1加权MRI量化评估区域大脑小叶体积.
分析来自全球ENIGMA-PD工作组的横截面体积数据.

主要方法:

基于深度学习的小脑分片被应用于2487名PD患者和1212名对照患者.
线性混合效应模型比较了不同霍恩和雅尔 (HY) 疾病阶段的小脑体积.
研究了小脑体积,运动严重程度和认知得分 (蒙特利尔认知评估) 之间的关联.

主要成果:

患有PD的个体整体上表现出较小的后脑叶.
早期的PD (HY阶段1) 与更大的双边前叶V相关.
晚期PD阶段 (HY 3-5) 呈现越来越小的双侧叶片VII,与疾病严重程度有关.
患有PD的认知障碍个体有减少的小脑总体积.

结论:

在PD中,前 (运动) 和后 (非运动) 小脑区域之间存在分离.
早期的PD阶段与扩大的运动区域相关,而后期的PD阶段的特征是减少的非运动区域.
这些发现突出了小脑在PD进展和认知衰退中的演变作用.

关键词:

这就是为什么MRI是MRI.帕金森病的疾病.小脑小脑是什么意思疾病的分期疾病的分期

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