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口腔裂和自发流产的母亲史:一个案例对照研究

Maria Carolina de Moraes Pereira¹, Carolina Maia Silva¹, Thaís Bernardes de Queiroz¹

¹Department of Post-Graduation in Rehabilitation Sciences, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Bauru, Sao Paulo, 17012-900, Brazil.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

|November 15, 2023

概括

之前的自发流产与巴西儿童的非综合征性口腔裂 (NSOC) 没有联系. 该研究没有发现自发流产后后期怀孕中NSOC的风险增加,这表明它不是一个独立的风险因素.

科学领域:

医学研究医学研究
公共卫生公共卫生
遗传学和流行病学

背景情况:

非综合性口腔裂 (NSOC) 是一个重大的公共卫生问题.
调查NSOC的病因因素对于预防策略至关重要.
以前的自发流产被认为是NSOC病因学的潜在危险因素.

研究的目的:

为了比较NSOC儿童的母亲与没有NSOC儿童的母亲的自发流产率.
为了确定自发流产史是否是随后怀孕中NSOC的风险因素.
分析巴西人口中自发流产和NSOC发生之间的关联.

主要方法:

一项涉及1004名参与者的病例控制研究 (502名患有NSOC儿童的母亲,502名对照).
标准化问卷被用来收集关于母亲自发流产史的数据.
统计分析包括描述性统计和千平方测试,具有5%的显著程度.

主要成果:

自发流产的发病率在病例组为16.3%,在对照组为15.9%.
在有或没有NSOC的孩子的母亲之间,没有观察到自发流产率的统计学上显著差异 (p=0.93).
根据裂口类型的子组分析也显示没有显著差异.

结论:

母亲的自发流产史与非综合征性口腔裂无关.
以前的自发流产似乎不是NSOC的独立风险因素.
这些发现是针对研究的巴西人口的具体发现.

关键词:

嘴唇裂口是一个问题.裂口口腔的 palatal palatal 是一个口腔裂口.流产流产流产流产有关风险因素的风险因素.这是自发流产.

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