早期的生活逆境共同调节体质指数和工作记忆的发展
Bence Csaba Farkas1,2,3,4, Pierre Olivier Jacquet1,2,3,4
1Université Paris-Saclay, UVSQ, Inserm, CESP, 94807, Villejuif, France.
Proceedings. Biological sciences
|November 15, 2023
概括
生命早期的逆境会影响大脑与身体之间的能量交易. 具体而言,贫困会对神经认知发育产生负面影响,对身体质量指数 (BMI) 的增长产生积极影响.
科学领域:
- 发育生物学是发展生物学.
- 神经科学是一个神经科学.
- 环境健康 环境健康
背景情况:
- 理论上,体和神经认知发育之间的能量分配涉及一个权衡.
- 早期生活环境因素对这种发展权衡的影响仍未得到充分探索.
研究的目的:
- 研究神经认知和体质发育轨迹之间的关联.
- 为了检查早期生活中的逆境对大脑和身体的能量权衡的缓和作用.
主要方法:
- 利用生长曲线建模来分析神经认知 (工作记忆) 和体质 (体质指数) 的发展轨迹.
- 在模型中纳入了多维的早期逆境 (剥夺,威胁,不可预测性).
主要成果:
- 证实了体质和神经认知生长之间的负面关系,与能量权衡一致.
- 早期的逆境与人体成长有积极的关联,与神经认知成长有负面的关联.
- 剥夺成为影响体质和神经认知成长模式的最重要的逆境维度.
结论:
- 在发育过程中,大脑与身体之间的能量权衡受到早期生活环境因素的调节.
- 现型可塑性在个人如何平衡能源分配,以应对环境影响,特别是贫困方面发挥着作用.
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