在患有口腔状细胞癌的患者中评估唾液转激素
Fatemeh Tavakoli1, Mohammad Ali Ghavimi2, Vahid Fakhrzadeh3
1Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Clinical and experimental dental research
|November 15, 2023
概括
在患有口腔状细胞癌 (OSCC) 的患者中,唾液转激素水平显著更高. 这一发现表明,转激素可以作为早期OSCC检测的有价值的生物标志物.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 生物标志物发现发现
背景情况:
- 口腔状细胞癌 (OSCC) 约占口腔癌的94%.
- 早期诊断OSCC至关重要,因为晚期的预后很差.
- 唾液生物标志物为非侵入性早期发现OSCC提供了潜在的潜力.
研究的目的:
- 研究唾液转激素作为口腔状细胞癌 (OSCC) 的生物标志物的潜力.
- 为了比较OSCC患者和健康个体之间的唾液转激素度.
主要方法:
- 一项涉及40名OSCC患者和40名健康对照者的病例控制研究.
- 从所有参与者身上收集了唾液样本 (5毫升).
- Salivary transferrin 度被量化并进行统计分析.
主要成果:
- 在OSCC组 (2.512毫升) 的平均唾液转激素度明显高于对照组 (1.234毫升).
- 标准偏差在OSCC组为0.463,在对照组为0.374.
- 在两组之间观察到统计学上显著的差异.
结论:
- 在患有口腔状细胞癌 (OSCC) 的个体中,唾液转激素的平均度较高.
- 唾液转激素显示为潜在的诊断生物标志物,可用于早期检测OSCC.
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