胎儿心脏左心室的功能变化在怀孕期间与母亲的甲状腺功能低下症
Miraç Özalp1, Simten Genç2, Gülçin Özalp3
1Cemil Tascioglu City Hospital, Perinatology, University of Health Sciences, Istanbul, Turkey.
Echocardiography (Mount Kisco, N.Y.)
|November 15, 2023
概括
孕产妇的甲状腺功能低下,无论是明显的还是亚临床的,都会在第二个三个月影响胎儿的心脏功能. 在亚临床甲状腺功能低下症中,抗甲状腺过氧化酶抗体的阳性进一步损害胎儿心脏功能.
科学领域:
- 内分泌学 在内分泌学.
- 胎儿医学 胎儿医学
- 心脏病学 心脏病学
背景情况:
- 孕产妇的甲状腺功能低下与不良妊娠结果有关.
- 胎儿心脏功能评估对于监测胎儿健康至关重要.
研究的目的:
- 在明显和亚临床甲状腺功能低下的怀孕中评估胎儿心脏功能.
- 为了确定Levothyroxine治疗和抗甲状腺过氧化酶抗体状态对胎儿心脏功能在亚临床甲状腺功能低下的影响.
主要方法:
- 心脏多普勒评估胎儿的心脏功能.
- 胎儿心脏功能参数的比较 (异体度放松时间和心肌性能指数) 在明显的甲状腺功能下降,亚临床的甲状腺功能下降和对照组之间.
- 在亚临床甲状腺功能低下组中分析了勒沃西治疗效果和抗TPO抗体状态.
主要成果:
- 与对照人群相比,胎儿心脏功能在明显的和亚临床的甲状腺功能下降症中显著受损.
- 在甲状腺功能低下组中,异体度放松时间和心肌性能的指数都较高.
- 在亚临床甲状腺功能低下症中,Levothyroxine治疗没有显著改变心脏功能参数.
- 在亚临床甲状腺功能低下症中,抗TPO抗体的阳性与显著更高的异体度放松时间和心肌性能指数有关.
结论:
- 母亲的明显和亚临床甲状腺功能低下症可以在第二个三个月的早期就影响胎儿的心脏功能.
- 在亚临床甲状腺功能低下症中,抗TPO抗体的阳性似乎会对胎儿心脏功能产生负面影响.
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