在接受免疫检查点抑制剂治疗的非小细胞肺癌患者中,肥胖悖论
Ji Hyun Lee1, Danbee Kang2, Jin Seok Ahn3
1Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Journal of cachexia, sarcopenia and muscle
|November 15, 2023
概括
在接受免疫检查点抑制剂的高级非小细胞肺癌患者中,肥胖 (高体重指数) 与更好的生存率有关,无论身体组成如何,如肌肉或脂肪质量. 这一发现为癌症治疗中的肥胖悖论提供了洞察力.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 身体组成分析 身体成分分析
背景情况:
- 肥胖悖论,即更高的BMI与某些疾病的更好结果相关,在接受免疫检查点抑制剂 (ICI) 的高级非小细胞肺癌 (NSCLC) 患者中观察到.
- 驱动这种悖论的潜在机制,特别是身体成分的作用,仍然不清楚.
研究的目的:
- 调查身体组成 (骨肌肉和内脏脂肪) 是否会改变亚洲患者的肥胖的预后影响,按BMI定义,亚洲患者患有先进的NSCLC,接受ICI治疗.
- 探索这个患者队伍中身体组成指标和整体存活率之间的关系.
主要方法:
- 用ICI治疗的820名患有晚期NSCLC的亚洲患者的回顾性分析 (2015年10月-2021年10月).
- 使用腹部CT成像计算骨肌肉和内脏脂肪指数.
- 考克斯比例危险回归用于评估BMI (亚太分类),身体成分和整体生存时间之间的相关性.
主要成果:
- 肥胖的BMI与较长的整体存活率显著相关,独立于临床因素 (HR,0.64;95% CI,0.52-0.80).
- 这种关联甚至在调整骨肌肉指数 (HR,0.68;95% CI,0.53-0.87) 或内脏脂肪指数 (HR,0.54;95% CI,0.41-0.70) 后也持续存在.
- 没有发现性别和BMI对存活率的影响之间的显著相互作用 (P > 0.05).
结论:
- 肥胖的BMI是亚洲高级NSCLC患者接受ICI的整体存活率的有利预后指标.
- 肥胖BMI对生存的有益影响独立于这个人群的骨肌肉质量或内脏脂肪含量.
- 在这种情况下,身体成分指标似乎没有调解观察到的肥胖悖论.
更多相关视频
06:03Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
17.1K
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
10.6K
相关概念视频
Obesity
509
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
509
Tumor Immunotherapy
533
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
533
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
COPD: Management Using Bronchodilators and Corticosteroids
217
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
217
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
