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一个单一组件的双重供体使超声波触发的一氧化碳和硫化的同时释放成为可能

Mengdan Zhang¹, Jian Cheng¹, Zhiqiang Shen¹

¹Department of Pharmacy, The First Affiliated Hospital of University of Science and Technology of China (USTC), and Key Laboratory of Precision and Intelligent Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui Province, 230026, China.

Angewandte Chemie (International ed. in English)

|November 15, 2023

概括

这项研究引入了一种新型的共聚物,在超声波刺激时释放一氧化碳 (CO) 和硫化 (H2S). 这种双重气传递剂疗法显示出强大的抗菌和抗炎作用,为感染提供了一种新的无抗生素治疗方法.

科学领域:

生物材料科学生物材料科学
纳米医学是一种纳米医学.
治疗性气体传递器的交付

背景情况:

开发双气传递体供体对于理解它们在疾病中的相互作用和提高治疗结果至关重要.
目前的多组件捐赠者面临局限性;需要一个单组件的响应系统来有效地输送气体传递物 (一氧化碳[CO]和硫化[H2S]).

研究的目的:

开发一种新型的,超声响应的,水溶性共聚合物,用于共同输送CO和H2S.
研究二重CO/H2S释放对抗细菌感染和炎症的治疗潜力.

主要方法:

合成了一种单组分,用硫替代的3-二黄 (SHF) 衍生物,并纳入水溶性共聚合物 (PSHF).
利用轻微的超声波照射来触发共聚物的分解和CO和H2S的释放.
评估了对黄金葡萄球菌的杀菌活性,对抗脂多糖糖挑战性巨细胞的抗炎作用,以及在败血性关节炎小鼠模型中的治疗疗效.

主要成果:

硫的替代显著提高了超声波的敏感性,使得高效的二氧化碳和H2S的同时释放.
释放的CO/H2S显示出对黄金色杆菌的显著杀菌作用和强大的抗炎活性.
在性关节炎大鼠中,超声波触发的CO/H2S局部释放显示出在没有抗生素的情况下更高的治疗效果.

结论:

开发的超声响应PSHF共聚物有效地从单个组件中提供双重气体传递物 (CO/H2S).
这种双重传气体系统在治疗细菌感染和炎症 (包括败血性关节炎) 方面显示出有前途的治疗潜力,作为一种无抗生素的替代方案.

关键词:

一氧化碳的一氧化碳.硫化是一种硫化.败血性关节炎是什么意思超声波超声波是指超声波的使用.

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