呼吸节奏调节了膜潜力和非嗅觉神经元的尖端
Maxime Juventin1, Mickael Zbili1,2, Nicolas Fourcaud-Trocmé1
1Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, Université Claude Bernard Lyon 1, CNRS, INSERM, Bron, France.
Journal of neurophysiology
|November 15, 2023
概括
呼吸节奏影响神经元膜潜力和非嗅觉大脑区域的尖端活动. 这表明呼吸作为大脑广泛沟通的主钟.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 研究表明,呼吸驱动器会影响大脑各区域的局部场潜力 (LFP).
- 呼吸节奏被提出为区域间大脑通信的潜在主钟.
- 关于呼吸是否在嗅觉系统之外形成膜电位 (MP) 振荡的知识有限.
研究的目的:
- 为了研究呼吸节奏是否调节神经元膜潜力 (MP) 在非嗅觉大脑区域的振荡.
- 为了确定呼吸是否会影响这些地区的尖端活动.
- 探索呼吸在中介远程大脑通信中的潜在作用.
主要方法:
- 在尿麻醉的老鼠中共同记录MP和LFP活动.
- 专注于非嗅觉大脑区域:中间前额叶皮质 (mPFC),主要体感皮质 (S1),主要视觉皮质 (V1) 和海马体 (HPC).
- 呼吸系统循环分析以确定与呼吸有关的振荡 (RRo).
主要成果:
- 发现呼吸在所有记录的非嗅觉区域都能调节MP和尖端排放.
- 这些调制发生在已识别的呼吸相关振荡 (RRo) 期间.
- RRo发作是短暂的,平均5次连续的呼吸周期,与LFP呼吸调节相关.
结论:
- 呼吸节奏影响神经元膜潜力和不同非嗅觉大脑区域的尖端活动.
- 这些发现支持了呼吸可以调解大脑区域之间的远程通信的假设.
- 呼吸节奏可以作为一个共同的时钟,同步大规模的神经网络动态.
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