大脑语言网络和前叶症儿童的认知结果
Alejandra M Hüsser1,2, Phetsamone Vannasing1, Julie Tremblay1
1Neurodevelopmental Optical Imaging Laboratory (LIONlab), Research Center, Sainte-Justine Mother and Child University Hospital Center, Montreal, QC, Canada.
Frontiers in human neuroscience
|November 15, 2023
概括
儿科前额叶和叶改变大脑语言网络,显示左半球连接性减少和儿童认知发育受损. 重组并不能确保最佳的大脑功能.
科学领域:
- 神经科学是一个神经科学.
- 儿科神经学 儿科神经学
- 认知科学 认知科学
背景情况:
- 儿科额叶和叶 (FLE,TLE) 与语言缺陷和大脑变化有关.
- 这些儿童语言网络重组的具体模式尚不清楚.
研究的目的:
- 在患有FLE或TLE的儿童中描述大脑语言网络.
- 研究大脑网络特征与认知能力之间的关联.
主要方法:
- 20名患有FLE/TLE的儿童和29名对照儿童接受了神经心理评估和同时进行fNIRS-EEG.
- EEG发现了亚临床发作;受影响的间隔从fNIRS分析中删除.
- 使用fNIRS信号的交叉相关性计算了功能连接矩阵.
主要成果:
- 组显示左半球和内半球连接性减少,右半球连接性增加,右半球局部效率提高.
- 患有的儿童在所有认知领域的表现明显较低.
- 在患者中,左半球局部效率与智商负相关.
结论:
- 儿科FLE/TLE中的大脑重组与改变的语言网络有关.
- 这些网络变化与认知发育受损和智商降低相关.
- 儿科的当前大脑重组模式可能不支持最佳的认知结果.
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