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化-9-双影响小鼠胚胎体的终端分化

Aidan J McLaughlin¹, Anthony I Kaniski¹, Darena I Matti¹

¹College of Arts Sciences and Letters, Department of Natural Science, University of Michigan-Dearborn, Dearborn, MI 48128, United States.

Current research in toxicology

|November 15, 2023

概括

-9-双 (BHPF) 破坏小鼠胚胎干细胞的自我更新和多能性,影响分化并可能导致炎症反应. 这凸显了对BHPFF的担忧.

科学领域:

干细胞生物学干细胞生物学
毒理学毒理学毒理学
发育生物学是发展生物学.

背景情况:

-9-双 (BHPF) 是工业上使用的双A (BPA) 替代品.
BHPF对胚胎干细胞 (ESC) 自更新,多能性和分化的影响在很大程度上是未知的.

研究的目的:

研究BHPF对小鼠胚胎干细胞 (mESCs) 和胚胎体 (EBs) 的影响.
了解BHPF对干细胞自我更新,多能性和分化途径的影响.

主要方法:

mESCs和EBs对BHPF的暴露.
对mESC殖民地的形态评估.
分析EB的形成和增长.
基因表达分析 (包括Il6和分化标志物).

主要成果:

暴露于BHPF减少了圆顶形殖民地,表明mESC自我更新和多能性的损失.
BHPF影响了EB的形成,减少了EB的数量并增加了它们的尺寸.
观察到炎症基因Il6的表达增加.
BHPF调节了16个参与终端分化成各种细胞类型的基因的表达.

结论:

暴露于BHPF会对mESC的自我更新,多能性和分化产生负面影响.
BHPF可能会诱导炎症反应并影响发育途径.
研究结果表明,环境BHPF暴露对发育和神经健康的潜在健康影响.

关键词:

在BHPF中,BHPF是最重要的.化-9-双二醇是一种在小鼠胚胎干细胞.终端区分区分的区分

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