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在糖尿病肺功能障碍中非亡性编程细胞死亡:高级糖化终产品的新方面

Yimin Dai¹, Shuang Zhou¹, Lin Qiao¹

¹Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital (PUMCH), Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.

Frontiers in endocrinology

|November 15, 2023

概括

新的研究探讨了糖尿病肺部疾病中的编程细胞死亡 (PCD). 非亡性PCD和AGE-RAGE轴是理解糖尿病并发症的关键因素.

科学领域:

肺部医学肺部医学
内分泌学在内分泌学.
细胞生物学细胞生物学

背景情况:

糖尿病是一种慢性代谢疾病,影响多个器官系统,包括肺部.
肺功能障碍是DM已知的并发症,但其机制仍然不完全理解.
传统的机制包括先进的糖化终产物 (AGEs),血管病,氧化应激和炎症.

研究的目的:

审查关于编程细胞死亡 (PCD) 在糖尿病肺功能障碍中的作用的新研究.
在糖尿病相关的肺部并发症的背景下突出非亡性PCDs (NAPCDs) 的重要性.
检查NAPCDs和AGE-RAGE轴在糖尿病肺部疾病发病过程中的相互作用.

主要方法:

关于糖尿病肺功能障碍的最近研究的文献综述.
专注于被编程的细胞死亡途径,特别是非细胞亡的形式.
对AGE-RAGE轴参与糖尿病肺病理和细胞死亡的分析.

主要成果:

非亡性PCD (NAPCD),包括自细胞死亡,亡,烧亡,铁亡和铜诱导的细胞死亡,与糖尿病及其并发症相关.
AGE-RAGE轴与传统的糖尿病肺病机制和NAPCD有关.
新出现的证据表明,NAPCD是糖尿病肺功能障碍的关键贡献者.

结论:

非亡性PCD代表了糖尿病肺功能障碍的重要,但尚未研究的领域.
AGE-RAGE轴是一个核心参与者,将传统途径与新型细胞死亡机制联系起来.
对NAPCD和AGE-RAGE轴的进一步研究可能会揭示糖尿病肺部疾病的新治疗点.

关键词:

先进的葡萄糖酶化最终产品.糖尿病肺功能障碍糖尿病肺功能障碍这是一种炎症炎症炎症炎症.非亡的编程细胞死亡.氧化应激是一种氧化应激.

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