儿童每月或每天服用维生素D3:一个回顾性倾向得分匹配的研究
Jinjoo Choi1, Yunsoo Choe2, Seung Yang1,3
1Department of Pediatrics, Hanyang University Seoul Hospital, Seoul, Republic of Korea.
Frontiers in endocrinology
|November 15, 2023
概括
每月补充维生素D3 (胆卡西费醇) 有效地纠正儿童的维生素D缺乏. 这种剂量方案为儿科患者提供了一种安全且可能更符合日常服用的替代方案.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏是儿童的全球健康问题.
- 维生素D补充的最佳剂量策略对于儿科健康至关重要.
- 过早的青春期管理往往需要仔细监测维生素D状态.
研究的目的:
- 在维生素D缺乏的儿童中,比较每月和每天维生素D3 (胆卡西费醇) 的疗效和安全性.
- 为了评估血清25-基维生素D [25(OH) D]水平和两种剂量方案之间的治疗结果.
- 评估是否有可能更好地遵守每月剂量计划.
主要方法:
- 一项回顾性研究将192名维生素D缺乏的儿童与早期青春期相匹配,使用倾向分数.
- 儿童每天接受1000 IU维生素D3或每4周接受25,000 IU.
- 关键的匹配因素包括年龄,性别,BMI Z-score,血液采集季节和基线血清25(OH) D.
主要成果:
- 每月服用维生素D3的组与每日服用维生素D3的组相比,血清25OH) D度显著增加 (10.9比8.2ng/mL).
- 月经组中更高比例的儿童达到血清25(OH) D水平>20ng/mL (78.1%对58.3%).
- 在这两组治疗中都没有报告过高血症病例,这表明这两种治疗方案的安全性概况都是有利的.
结论:
- 每月服用维生素D3是一种有效和安全的替代方案,用于纠正儿科患者的低维生素D.
- 改善的疗效可能与患者对较少剂量治疗的遵守程度提高有关.
- 这一策略有望改善儿童的维生素D状况,特别是那些患有需要定期药物治疗的慢性疾病的儿童.
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