为流感门诊患者和随后住院的门诊患者开处方抗生素:使用保险数据的队列研究
Hiroshi Yokomichi1, Mie Mochizuki2, Joseph Jonathan Lee3
1Department of Epidemiology and Environmental Medicine University of Yamanashi Chuo Japan.
Influenza and other respiratory viruses
|November 15, 2023
概括
在门诊患者中与流感抗病毒药物一起使用抗生素可能会增加住院的风险和肺炎的持续时间. 需要进一步的研究来澄清流感治疗的这些关联.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 预防性抗生素在减少流感住院病人的作用尚不清楚.
- 这项研究调查了流感门诊患者的抗生素处方和随后的住院治疗之间的联系.
研究的目的:
- 检查流感感染的门诊患者处方抗生素和随后住院治疗之间的关联.
- 分析抗生素对流感患者住院风险和住院时间的影响.
主要方法:
- 一项队列研究利用了日本医疗保险记录 (2012-2016).
- 包括0-74岁的门诊患者,确诊流感,接受抗流感药物治疗.
- 主要结局:住院的风险 (所有原因,肺炎) 和肺炎住院时间.
主要成果:
- 分析了903,104个门诊病例记录;2469次住院治疗.
- 抗流感药加抗生素与单独抗流感药的住院风险更高.
- 添加抗生素与较长的肺炎住院时间相关 (4.12 vs 3.77 天).
- 接受补充抗生素的老年患者 (65-74岁) 的肺炎住院时间更短 (不显著).
结论:
- 在门诊患者的抗病毒流感治疗中添加的抗生素与住院风险增加有关.
- 这些患者还因肺炎而经历了更长的住院时间.
- 研究结果表明,对于常规的流感抗生素联合处方,应该谨慎.
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