在产后阶段和再生过程中,Pcdh19调解嗅觉感官神经元凝聚
Andrew P Martinez1, Alexander C Chung1, Suihong Huang2
1Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA.
iScience
|November 15, 2023
概括
核素19 (Pcdh19) 突变破坏了嗅觉感官神经元的再生,影响了嗅觉地图,特别是在男性中. 这表明Pcdh19对于在嗅觉系统修复过程中维持神经连接至关重要.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 小鼠的嗅觉系统在整个生命过程中都会不断地再生.
- 引导初始嗅觉感官神经元 (OSN) 投射的基因已知,但再生期间的维护基因并非如此.
研究的目的:
- 研究Protocadherin 19 (Pcdh19) 在OSN再生期间维持嗅觉图的作用.
- 为了确定OSN凝聚和地图完整性后再生至关重要的基因.
主要方法:
- 使用了一种具有Pcdh19基因突变的小鼠模型.
- 进行单细胞分析,检查OSN种群和基因表达.
- 研究了中间和侧面质体中的嗅觉地图组织,比较性别.
主要成果:
- Pcdh19突变在再生过程中引起了OSN凝聚的缺陷,影响了嗅觉图.
- 侧面球粒和雄性小鼠表现出更严重的表型.
- 单细胞分析揭示了OSN内部表达MOR28气味受体的细分.
- 在中间和侧面质细胞中,在OSN之间观察到protocadherins的基因表达差异.
- 发现了基因表达的性别差异,这可能解释了差异突变效应.
结论:
- 在再生过程中,PCdh19对于正确的OSN凝聚和嗅觉地图维护至关重要.
- 这项研究强调了Pcdh19在嗅觉系统中的性别和区域特异性的作用.
- 不同的基因表达模式可能是再生缺陷中观察到的性二态和质特异性的基础.
更多相关视频
06:32Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
Published on: June 5, 2017
7.2K
10:42A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
Published on: August 18, 2014
9.0K
相关概念视频
Olfactory Receptors: Location and Structure
9.3K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.3K
Physiology of Smell and Olfactory Pathway
8.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.6K
Olfaction
44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.4K
Neurogenesis and Regeneration of Nervous Tissue
832
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
832
