在患有冠状病毒疾病2019肺炎的患者中LDH的影响
Tong Mu1, Xingguang Wang2, Zhiming Lu3
1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong First Medical University, Jinan, Shandong, China.
Frontiers in cellular and infection microbiology
|November 15, 2023
概括
血清乳酸脱酶 (LDH) 水平与COVID-19肺炎的严重程度相关. 升高的LDH有助于早期诊断和预后评估2019年冠状病毒病 (COVID-19) 患者,为临床管理提供有价值的见解.
科学领域:
- 生物化学 生物化学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 新型冠状病毒 (SARS-CoV-2) 导致2019年冠状病毒病 (COVID-19),这是一个严重程度可变的呼吸系统疾病.
- 早期诊断和预后评估对于有效管理COVID-19肺炎至关重要.
研究的目的:
- 调查血清乳酸脱酶 (LDH) 水平对于早期诊断COVID-19肺炎的有用性.
- 评估血清LDH的预后值,以评估COVID-19肺炎的严重程度和预测结果.
主要方法:
- 对101名COVID-19肺炎患者的回顾性分析,根据初始胸部CT严重程度和治疗反应分类.
- 在普通和严重的肺炎组之间,以及在缓解和非缓解组之间比较临床特征,实验室发现和成像结果.
- 使用接收器操作特征 (ROC) 曲线和曲线下的面积 (AUC) 来评估LDH的诊断性能.
主要成果:
- 与普通肺炎患者相比,严重的COVID-19肺炎患者的血清LDH水平显著更高.
- 升高的LDH和中性粒细胞计数独立与COVID-19肺炎恶化有关.
- LDH在区分普通和严重的肺炎 (AUC = 0.833) 和结合中性粒细胞数量时,在预测缓解 (AUC = 0.759) 中表现出诊断能力.
结论:
- 血清LDH是一种与COVID-19肺炎严重程度相关的有价值的生物标志物.
- LDH水平可以作为评估COVID-19肺炎患者预后的重要指标.
相关概念视频
Muscle Recovery and Fatigue
2.1K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.1K
Pneumonia IV: Management
338
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
338
Pneumonia III: Complications and Assessment
241
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
241
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Acute Respiratory Failure-III
190
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
190
Diagnosing Acidosis and Alkalosis
232
Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
Next, the PCO2 and...
232


