在急性发作期间,双相情绪障碍患者的嗅觉功能受损,无论精神病症状如何
Yingying Li1, Huiqian Yuan1, Xianlin Liu1
1Department of Psychiatry, Shunde WuZhongpei Memorial Hospital, Foshan, China.
Frontiers in psychiatry
|November 15, 2023
概括
嗅觉识别 (OI) 在双相情感障碍 (BD) 患者中受损,无论精神病症状如何. 嗅觉敏感性 (OS) 在发作期间受损,但在缓解期间恢复,这表明它可能会区分BD状态.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 感官科学 感官科学
背景情况:
- 双极性障碍 (BD) 是一种情绪障碍,其特点是躁狂和抑郁症.
- 在各种精神疾病中报告了嗅觉功能障碍,包括BD.
- 精神病症状和疾病状态 (发作与缓解) 对BD嗅觉功能的影响仍然不清楚.
研究的目的:
- 研究精神病症状对双相情感障碍 (BD) 患者嗅觉功能的影响.
- 为了在BD患者中比较急性情节和缓解阶段之间的嗅觉功能.
- 为了探索BD的潜在嗅觉标记物.
主要方法:
- 嗅觉灵敏度 (OS) 和嗅觉识别 (OI) 在BD患者和健康对照者 (HC) 中使用Sniffin' Sticks测试进行评估.
- 患者被分为患有精神病症状的BD (P-BD),没有精神病症状的BD (NP-BD),情节性BD和euthymicBD组.
- 精神和社会功能被评估使用标准化尺度 (HAMD,YMRS,HAMA,PANSS,GAF).
主要成果:
- 与HC相比,P-BD和NP-BD两组都显示OI受损,P-BD和NP-BD之间没有显著差异.
- 与HC相比,所有插曲性BD患者的OS和OI显著减少.
- 优性BD患者已经恢复了OS (类似于HC),但保留了受损的OI.
结论:
- 情节性BD与嗅觉缺陷 (OS和OI) 相关,无论精神病特征如何.
- 嗅觉识别 (OI) 可能作为双相情感障碍的特征标志物.
- 嗅觉敏感性 (OS) 似乎是一个状态标志物,在BD中区分急性发作和缓解.
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