Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Tumor Necrosis Factor Inhibitors.

Acta naturae·2026
Same author

[Detection of highly pathogenic orthopoxviruses (<i>Poxviridae</i>: <i>Chordopoxvirinae</i>: <i>Orthopoxvirus</i>) by dot immunoassay in a high-containment biological safety laboratory].

Voprosy virusologii·2025
Same author

[The results of the detection of specific IgG antibodies to Ebola virus (Filoviridae: <i>Orthoebolavirus</i>) in residents of the Republic of Guinea after the end of the epidemic].

Voprosy virusologii·2025
Same author

The Humoral and Cellular Immune Response to the Administration of OrthopoxVac Vaccine to Volunteers.

Acta naturae·2025
Same author

[Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection].

Molekuliarnaia biologiia·2025
Same author

An Attenuated and Highly Immunogenic Variant of the Vaccinia Virus.

Acta naturae·2024
Same journal

Transcriptional changes of aquaporin genes in leaves of black medic induced by arbuscular mycorrhizal fungal inoculation under water deficit.

Vavilovskii zhurnal genetiki i selektsii·2026
Same journal

Genetic analysis of wheat ear architecture in F2 hybrid of tetraploid wheats Triticum aethiopicum and T. carthlicum and its computer phenotyping.

Vavilovskii zhurnal genetiki i selektsii·2026
Same journal

Diagnostic efficiency of whole exome sequencing in the search for genetic causes of hereditary diseases in Yugra (West Siberia, Russia).

Vavilovskii zhurnal genetiki i selektsii·2026
Same journal

Development of a molecular marker for the Run8 gene for the selection of barley genotypes resistant to smut.

Vavilovskii zhurnal genetiki i selektsii·2026
Same journal

Rare variants in cholesterol transporter genes in patients with lipid metabolism disorders.

Vavilovskii zhurnal genetiki i selektsii·2026
Same journal

Evolutionary inferences from the analysis of mutation dynamics in the SARS-CoV-2 replication-transcription complex.

Vavilovskii zhurnal genetiki i selektsii·2026
查看所有相关文章

相关实验视频

Updated: Jul 11, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.7K

在小鼠模型中进行天花疫苗接种.

S N Shchelkunov1, A A Sergeev2, S A Pyankov2

  • 1State Research Center of Virology and Biotechnology "Vector", Rospotrebnadzor, Koltsovo, Novosibirsk region, Russia Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Vavilovskii zhurnal genetiki i selektsii
|November 15, 2023
PubMed
概括
此摘要是机器生成的。

皮内天花疫苗接种会引起比皮肤痕更强的保护性免疫力. 这种方法可以确保更深层次的抗体产生,并更好地保护小鼠免受牛病毒的挑战.

关键词:
皮肤内注射的内皮注射这就是麻疹.皮肤痕,皮肤痕.小型天花 在天花.接种疫苗 接种疫苗疫苗病毒病毒病毒病毒病毒.

更多相关视频

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.4K
In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
07:05

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model

Published on: November 28, 2017

9.9K

相关实验视频

Last Updated: Jul 11, 2025

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

10.7K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.4K
In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
07:05

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model

Published on: November 28, 2017

9.9K

科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学
  • 病毒学 病毒学

背景情况:

  • 2022年疫情凸显了有效的天花疫苗接种策略的必要性.
  • 现代疫苗是通过肌肉内注射或通过皮肤化进行的,但肌肉内注射途径在免疫学上很差.
  • 皮肤是免疫学上重要的器官,这表明皮内输送可以增强免疫力.

研究的目的:

  • 为了比较皮肤内 (i.d.) 的疗效. 对于天花疫苗接种的皮肤化 (s.s.) 路径.
  • 在小鼠模型中评估低剂量,第二代和第四代疫苗病毒 (VACV) 疫苗.
  • 评估不同疫苗接种途径引起的抗体产生和保护性免疫力.

主要方法:

  • 在BALB/c小鼠接种LIVP或LIVP-GFP VACV菌株,通过i.d.接种. 或S.S.路线.
  • 用ELISA在注射后的多个时间点测量VACV特异性IgM和IgG抗体标位.
  • 给小鼠提供了致命剂量的牛病毒,以评估保护性免疫力.

主要成果:

  • 皮肤内接种疫苗导致VACV特异性IgM和IgG抗体标位与s.s.路线相比显著更高.
  • 两种VACV菌株的皮内注射赋予了对致命牛病毒的更强的保护性免疫力.
  • 在I.D.的ID. 这种途径在引起强大的免疫反应和保护方面更有效.

结论:

  • 与皮肤痕相比,皮肤内注射疫苗是获得针对疫苗病毒的保护性免疫力的优越方法.
  • 用现代天花疫苗变体进行低剂量皮内疫苗接种为增强免疫提供了一个有希望的策略.
  • 这项研究支持皮肤内输送系统的开发,以提高疫苗的疗效.