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Updated: Jul 11, 2025

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对PI3KCA抑制剂,alpelisib的二次性面部白风:病例报告

Maayan Geller Hinich1, Adham Hijab1,2

  • 1Oncology Division, Ziv Medical Centre, Safed, Israel.

Frontiers in oncology
|November 15, 2023
PubMed
概括

乳腺癌药物Alpelisib可能会导致白风,这是一种导致皮肤脱色的疾病. 这是第一个报告的病例,表明alpelisib和这种不可逆转的副作用之间存在联系.

关键词:
这就是PIK3CA.在阿尔佩里斯比利斯,它是可靠的.乳腺癌 乳腺癌 乳腺癌皮肤不良影响不良影响在白风,白风.

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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