作为结直肠癌的预后指标的萨尔科佩尼亚:一个更新的元分析
Jie He1,2,3, Wei Luo1,4, Yuanyuan Huang1,2,3
1Clinical Medical College of Chengdu Medical College, Chengdu, Sichuan, China.
Frontiers in oncology
|November 15, 2023
概括
肌肉质量的丧失,即萨尔科佩尼亚,与结直肠癌患者的生存率较差有关. 这一元分析证实了sarcopenia作为总体,无病和癌症特异性生存的显著预后指标.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 放射学 放射学是一门学科.
背景情况:
- 标志着骨肌肉质量和功能的减少的萨尔科佩尼亚在老年人中很普遍,并且与癌症的不良结果有关.
- 计算机断层扫描 (CT) 用于测量骨肌肉指数 (SMI) 在L3脊椎,这是麻症的关键诊断标准.
- 在结直肠癌 (CRC) 中,萨科佩尼亚的预后值需要全面评估.
研究的目的:
- 为了评估被诊断患有结直肠癌的患者中萨尔科佩尼亚的预后意义.
- 分析萨科佩尼亚和生存结果之间的关联,包括总生存率 (OS),无病生存率 (DFS) 和癌症特异性生存率 (CSS).
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,WANFANG,CNKI) 进行了系统的文献搜索,截至2023年6月.
- 包括的研究使用纽卡斯尔-太华尺度 (NOS) 进行了质量评估.
- 用于生存分析,提取了95%置信区间 (CI) 的危险比率 (HR),并使用STATA 11.0汇总了数据.
主要成果:
- 包含元分析的20篇文章显示,结肠直肠癌患者中皮症的发病率为34%.
- 萨科佩尼亚与下降的OS (HR=1.72),DFS (HR=1.42) 和CSS (HR=1.48) 显著相关.
- 亚组分析证实了总体发现,加强了萨科佩尼亚对生存的负面影响.
结论:
- CT定义的肉类是患有结直肠癌的个体生存的有希望的预后生物标志物.
- 建议进一步研究标准化的肉症定义,以验证这些发现并提高临床适用性.
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