在机构队列中,在用阿斯巴拉金纳治疗期间获得的凝血因子缺陷
Vasiliki Papadopoulou1, Giulia Schiavini1
1Service and Laboratory of Hematology, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
阿斯巴拉基纳斯治疗可以延长激活的部分血栓形成时间 (aPTT),这是由于凝血因子FIX和FXI的水平降低. 这种效应,可能是由于因子合成受损,对于监测患者服用抗凝剂至关重要.
科学领域:
- 血液学 血液学 血液学
- 临床药理学 临床药理学
背景情况:
- 阿斯巴拉金酶是一种关键的化疗剂.
- 临床医生经常在接受阿斯巴拉金酶的患者中观察到延长的激活部分血栓形成时间 (aPTT).
- 这种常见的观察在现有的文献和指导方针中没有得到广泛报道或理解.
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