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不同的抗生素治疗A组链球菌喉炎的不同治疗方法
Katarina Hedin1,2,3, Sarah Thorning4, Mieke L van Driel5
1Futurum - the Academy for Health and Care, Region Jönköping County, Jönköping, Sweden.
The Cochrane database of systematic reviews
|November 15, 2023
概括
抗生素对喉疼痛的益处有限,如果需要治疗,青素仍然是可行的选择. 有证据表明,在某些情况下,卡巴塞可能比青素更好地缓解症状.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 治疗喉疼痛的抗生素只能带来适度的益处,在A组β-血液溶解性链球菌 (GABHS) 感染中有效性增加.
- 对GABHS桃体炎的最佳抗生素选择尚不清楚,需要进行比较疗效评估.
- 本综述是对先前针对 estreptococcal 喉炎的抗生素治疗方法分析的更新.
研究的目的:
- 为了比较不同抗生素在缓解症状,缩短疾病持续时间和预防GABHS桃体炎的临床复发和并发症方面的疗效.
- 评估与各种抗生素治疗相关的不良反应的比较发生率.
- 为了评估抗生素治疗链球菌喉炎的整体风险-益处概况.
主要方法:
- 随机,双盲试验的系统审查和元分析,比较不同的抗生素用于GABHS桃腺炎.
- 搜索包括主要的数据库 (CENTRAL,MEDLINE,Embase,Web of Science) 到2023年3月.
- 数据提取和偏差风险评估遵循Cochrane方法;用于证据确定性的GRADE方法.
主要成果:
- 关于类,类和青素之间症状缓解和临床复发的差异存在不确定性.
- 低确定性证据表明,卡巴塞可能比青素更好地解决症状.
- 在特定的试验中,与青素和氨基素相比,宏类药物和亚齐思罗米的不良反应更为常见,分别是青素和氨基素.
结论:
- 抗生素对GABHS桃体炎的影响有限,当抗生素治疗被指示时,青素仍然是合适的选择.
- 低确定性证据表明,卡巴塞在儿童的症状缓解方面可能比青素更有效.
- 由于缺乏有关风险人群并发症的数据,需要在低收入国家进行进一步的研究.
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