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在一般人群中血清铜水平和中风之间的关联:一项全国代表性的研究
Zhiqiang Chen1, Xiao Liu2, Yifan Wu3
1Department of Cardiovascular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China.
概括
较高的血清铜水平与美国成年人中风的患病率增加有关. 这一发现表明,铜可能在中风的发展中发挥作用.
科学领域:
- 生物化学 生物化学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 血清铜是各种生理过程中必不可少的微量元素.
- 升高的铜水平已与氧化应激和炎症有关,这可能导致脑血管疾病.
研究的目的:
- 调查血清铜度与中风患病率在美国成年人代表样本中的关联.
- 为了确定较高的血清铜水平是否与中风风险增加相关.
主要方法:
- 从三个国家健康和营养检查调查 (NHANES) 周期 (2011-2016) 的数据分析.
- 使用加权的多变量逻辑回归模型来评估血清铜三位数与中风患病率之间的关系.
- 进行了剂量反应分析,以评估关联的线性.
主要成果:
- 总共包括5151名成年人,其中181人 (3.51%) 报告有中风病史.
- 血清铜含量最高的三位数 (>19.8μmol/l) 个体与最低的三位数相比,中风的几率比率 (OR) (2.36;95% CI:1.01-5.52) 显著更高.
- 血清铜的每一个标准偏差增加都与中风的几率增加了44% (OR: 1.44;95%CI: 1.11-1.86),这表明正线性关联.
结论:
- 这项横截面研究表明,血清铜水平升高与美国成年人中卒中患病率之间存在显著的正相关性.
- 血清铜含量较高可能代表潜在的中风风险因素或生物标志物.
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