来自Phlegmariurus carinatus的Lycopodium类化合物具有细胞毒性和神经保护作用
Qiang Wang1, Dong-Kun Zheng2,3, Shu-Ping Jiang1,4,5
1Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou, 341000, China.
Chemistry & biodiversity
|November 15, 2023
概括
研究人员从Phlegmariurus carinatus中分离出了新类化合物,发现一种化合物,phlegmariurine B,通过抗亡途径防止细胞死亡,显示出神经保护的希望.
科学领域:
- 自然产品化学 自然产品化学
- 神经药理学神经药理学
背景情况:
- 弗莱格马里乌鲁斯·卡里纳图斯 (Phlegmariurus carinatus) 是各种类化合物的植物来源.
- 类化合物具有众所周知的多种生物活性,包括潜在的神经保护作用.
研究的目的:
- 从Phlegmariurus carinatus中分离和描述新的和已知的化物.
- 评估这些孤立化合物的细胞毒性和神经保护作用.
主要方法:
- 使用色谱技术分离类化合物.
- 通过核磁共振 (NMR) 谱学和高分辨率电喷射电离化质谱学 (HR-ESI-MS) 阐明结构.
- 使用电子循环二元制 (ECD) 确定绝对配置.
- 细胞毒性和神经保护性活动的体外测定.
主要成果:
- 确定了一种新的fawcettimine类型化物,弗莱卡里纳丁A (1),以及十二种已知的化物 (2-13).
- 没有任何化合物对测试的瘤细胞系表现出显著的细胞毒性活性.
- 弗莱格玛氨酸B (2) 显示神经保护作用,对HT22细胞的血红素诱导的损伤,增加细胞存活率17.76%在10μM.
- 发现木氨酸B (2) 可以通过抗亡机制改善神经元细胞死亡.
结论:
- 弗勒格玛氨酸B (2) 是一种有前途的化合物,用于开发神经保护剂.
- 这项研究扩大了从Phlegmariurus carinatus中化物的化学知识及其潜在的治疗应用.
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