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慢性酒精和尼古丁的消费作为系统性炎症风暴和骨破坏的催化剂在顶端牙周炎
Karem Paula Pinto1, Tatiana Kelly da Silva Fidalgo2, Carolina Oliveira de Lima3
1Department of Integrated Clinical Procedures, School of Dentistry, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
International endodontic journal
|November 15, 2023
概括
慢性酒精和尼古丁消费对大鼠的周围骨健康和全身标志物产生负面影响. 酒精和尼古丁的联合使用加剧了这些对骨微观架构和代谢概况的有害影响.
科学领域:
- 口腔生物学 口腔生物学
- 毒理学 毒理学 毒理学
- 生物化学 生化学
背景情况:
- 慢性酒精和尼古丁使用在全球普遍存在.
- 阿皮性牙周炎是一种常见的内牙并发症.
- 酒精和尼古丁对周围骨健康和全身标记物的联合影响尚未完全理解.
研究的目的:
- 为了研究慢性酒精和尼古丁消费对周围气膜骨的影响.
- 为了评估诱导牙周围炎的老鼠的血清水平的促炎性细胞因子,生物化学标记物和代谢物.
- 为了确定酒精和尼古丁的联合使用是否会加剧这些影响.
主要方法:
- 威斯塔老鼠被分为控制,酒精,尼古丁和酒精+尼古丁组.
- 慢性酒精消费是通过自我给药和尼古丁通过腹腔内注射诱导的.
- 牙周炎是由肉暴露引起的;用微型CT分析了牙周骨,并分析了血清中细胞因子,生物化学标记物和代谢物.
主要成果:
- 酒精或尼古丁的消费导致了变化的周围骨格模式,骨密度降低,IL-1β,IL-6和TNF-α水平增加.
- 在肝酶 (AST,ALT),脂质样本,功能标记物 (尿素,肌素) 和代谢物 (糖氨酸,乳酸,脂质) 中观察到显著的变化.
- 与单一物质使用相比,同时饮用酒精和尼古丁会导致更明显的有害影响.
结论:
- 慢性酒精和尼古丁的消费会在顶端牙周炎的背景下对周骨微型架构产生负面影响.
- 这些物质会损害肝脏和脏功能,并增加全身炎症.
- 酒精和尼古丁的联合摄入协同增强了这些不良影响.
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