妊娠期体重增加,妊娠期糖尿病和儿童肥胖发生率之间的关联
Nadia M Sneed1,2, William J Heerman3, Pamela A Shaw4
1Department of Pediatrics, Vanderbilt University Medical Center, 2146 Belcourt Ave., Nashville, TN, 37212, USA. nadia.sneed@vanderbilt.edu.
Maternal and child health journal
|November 15, 2023
概括
过度的孕产妇体重增加预示着儿童肥胖,但孕期糖尿病 (GDM) 似乎是保护性的. 季度特定的收益显示了各种风险,早期的收益与较低的风险相关,而后期的收益与更高的风险相关.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 过度的孕期体重增加 (GWG) 是儿童肥胖的一个已知的危险因素.
- 母亲GWG,妊娠期糖尿病 (GDM) 和儿童早期肥胖症之间的相互作用仍然不清楚.
研究的目的:
- 调查总体和季度特定的母体GWG和GDM与6岁后代肥胖之间的关联.
- 探索GWG和GDM在预测儿童肥胖症方面的潜在相互作用.
主要方法:
- 通过使用电子健康记录,分析了10,335个母婴二合一的队列.
- 使用功能主要成分分析估计了孕产妇体重轨迹.
- 使用卡普兰-梅尔曲线和Cox回归与通用拉来评估儿童时期肥胖的时间.
主要成果:
- 母亲GWG是儿童早期肥胖的一个显著预测因素 (p < 0.0001).
- 患有GDM的母亲的孩子患肥胖的风险较低 (调整后的危险比率=0.58,p=0.014).
- 较高的第一季度GWG与较低的肥胖风险相关 (p = 0.0002),而第二和第三季度GWG与更高的风险相关 (p < 0.0001).
结论:
- 总体和季度特定的母亲GWG强烈预测了儿童肥胖症.
- 母亲的GDM与儿童肥胖的风险降低有关,这与预期相反.
- 需要进一步的研究来了解将三个月特定的GWG和GDM与儿童肥胖风险联系在一起的机制.
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