使用生物电阻分析评估下体负压诱导的低血压期间血液体积的变化
Suthawan Anakmeteeprugsa1,2, Antonio Gonzalez-Fiol1, Rostislav Vychodil3
1Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA.
Journal of clinical monitoring and computing
|November 15, 2023
概括
身体下部负压 (LBNP) 导致血液聚集,改变生物阻抗. 上肢阻抗增加,而下肢阻抗减少,反映了身体对模拟出血的反应.
科学领域:
- 生理学 生理学 生理学
- 生物医学工程 生物医学工程
- 血液动力学 血液动力学
背景情况:
- 身体下部负压 (LBNP) 通过在下肢聚集血液来模拟急性出血.
- 生物电阻分析 (BIA) 测量组织的电特性,对血液体积变化敏感.
- 了解低血压期间的生物阻抗变化对于监测血液动力学状况至关重要.
研究的目的:
- 为了研究LBNP诱导的低血症期间上肢和下肢生物阻抗的变化.
- 在受控的低血压模型中,将生物阻抗变化与估计的血液损失相关联.
主要方法:
- 对健康志愿者进行前性观察研究.
- 从 -15到 -60 mmHg的逐步LBNP协议与恢复阶段.
- 在每个LBNP阶段测量上肢和下肢的生物阻抗.
主要成果:
- 上肢生物阻抗的显著增加和下肢生物阻抗的减少随着低血症的进展.
- 在康复阶段观察到的相互变化,下肢增加和上肢生物阻抗减少.
- 在上肢 (R=0.97) 和下肢 (R=-0.97) 估计的血液损失和生物阻抗变化之间发现了强烈的相关性.
结论:
- 上肢和下肢生物阻抗的相互变化发生在LBNP诱导的低血症期间.
- 这些生物阻抗转移反映了血液动力学补偿机制,以应对减少的血液体积.
- BIA显示出作为评估低血压和出血的非侵入性工具的潜力.
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