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关于黄素与其生物可用性和对恶性疾病的影响的临床试验:批判性分析

Marten A Khosravi¹, Roland Seifert²

¹Institute of Pharmacology, Hannover Medical School, Carl-Neuberg-Straße 1, D-30625, Hannover, Germany.

Naunyn-Schmiedeberg's archives of pharmacology

|November 15, 2023

概括

这次审查没有发现强有力的证据表明黄素有效治疗恶性疾病. 虽然一些研究表明生物可用性得到改善,但独立研究尚未证实这一点,质疑其治疗用途.

科学领域:

药理学药理学是指药理学的学科.
在瘤学瘤学.
自然产品自然产品

背景情况:

黄素是从长黄 (Curcuma longa) 衍生出来的,因其潜在的抗炎症和抗癌性质而闻名.
黄素治疗应用的一个显著限制是其固有的低生物可用性.
尽管有其所谓的益处,但缺乏强有力的临床证据支持黄素在治疗恶性疾病中的有效性.

研究的目的:

系统地审查和批判性地分析关于黄素的药理动力学 (生物可用性) 和其在治疗恶性疾病中的疗效的临床研究.
评估支持黄素在癌症治疗中使用的科学证据.
评估报告中的生物可用性增强的可靠性.

主要方法:

在clinicaltrials.gov和PubMed.gov上进行文献搜索.
根据曲素对曲素生物可用性和癌症治疗的相关性,过了293项研究.
分析了研究结果,研究设计 (随机化,安慰剂,掩盖,伦理,赞助) 和研究结果.

主要成果:

分析没有给出令人信服的证据表明黄素在治疗恶性疾病方面具有显著的积极作用.
一些研究报告了关于黄素生物可用性增加的积极结果,通常与制药行业有关.
独立研究和现有文献评论未能始终地证明增强的生物可用性或疗效.

结论:

目前的科学证据不支持黄素用于治疗恶性疾病.
报告的生物可用性增强需要进一步的独立验证.
根据审查的临床研究,黄素在癌症治疗中的有效性仍然没有得到证实.

关键词:

生物可用性生物可用性库尔库明是一种黄素.黄瓜类药物 (Curcuminoids) 是一种类药物.恶性疾病是恶性疾病.黄是一种黄.临床其他.gov.gov 在pubmed.gov网站上查看.

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