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在有限元素框架内神经驱动的3D肌肉激活:探索健康和神经退行性模拟中的应用

Colton D Babcock¹, Victoria L Volk¹, Wei Zeng²

¹Mechanical and Biomedical Engineering, Boise State University, Boise, ID, USA.

Computer methods in biomechanics and biomedical engineering

|November 15, 2023

概括

这项研究介绍了神经驱动肌肉模型的计算框架,模拟了肌缩性侧面硬化症 (ALS) 的影响. 该模型预测ALS患者的肌肉力量减少,有助于神经退行性疾病研究.

科学领域:

计算生物学是一种计算生物学.
神经科学是一个神经科学.
生物力学生物力学

背景情况:

肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病,影响运动神经元.
需要准确的计算模型来理解神经肌肉功能和疾病进展.

研究的目的:

为神经驱动的有限元素肌肉模型开发一种新的计算框架.
应用这个框架来模拟ALS对肌肉力量产生的影响.

主要方法:

创建了一个多尺度神经肌肉骨 (NMS) 模型,集成运动神经元,3D肌肉几何和纤维招募.
该模型通过预测健康的肌肉力量和肌延长来验证.

主要成果:

该模型成功预测了健康的肌肉功能.
在模拟的ALS进展中,肌肉力量逐渐下降,在发病120天后从203N下降到155N.

结论:

这种新的框架使得对像ALS这样的神经退行性疾病的预测性NMS模拟成为可能.
它代表了一步走向综合神经和肌肉骨建模,以提高对神经疾病的理解.

关键词:

神经肌肉模型的建模有限元素的元素是有限的.肌肉激活肌肉激活神经驱动的神经驱动.这是一种神经退行性疾病.

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